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Nitric oxide (NO) is a free radical gas molecule produced endogenously from L-arginine, oxygen, and NADPH by an enzyme nitric oxide synthase (NOS) [139]

LPS, in particular, has been shown to increase the permeability of the BBB, allowing immune cells and inflammatory mediators to infiltrate the brain, exacerbating cognitive dysfunction (Takata et al., 2021)

The production of acetate esters is also substrate dependent, relying on the availability of fusel alcohols (Lilly et al

Selenium and Gut Microbiome The gut microbiota is an ecosystem of individual microorganisms that inhabit the human gastrointestinal tract [91]

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Additionally, Glutathione aids in detoxifying the liver, enhancing its ability to remove toxins and heavy metals from the body, which can lead to improved energy levels and overall well-being