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For many patients, there may be long periods with no symptoms at all, followed by flare-ups
Statements Author contributions GG: Writing original draft
10.2217/17435889.2.2.233 [DOI] [PubMed] [Google Scholar] Singh S., Khar A
SoleCGuillySDa SilvaKLlopisMLe-ChatelierEHuelinPet al
However, it has also been reported that the PPP flux decrease may be an early event in the pathogenesis of sporadic PD, because in the later stages of PD, PPP flux is up-regulated in an attempt to counteract persistent oxidative stress [117]
