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While published research generally reports favorable tolerability, comprehensive long-term human safety studies have not yet been completed

Conclusions Despite recent advances in obesity pharmacotherapies, the need for improvements in medication efficacy, whilst minimising adverse effects, remains

The zonulin-induced disruption of the tight junction complex allows paracellular transport of gliadin and the eventual uptake of gliadin into systemic circulation, thereby causing the inflammatory response exhibited by patients with celiac disease (26, 34, 35)