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) Method for preparing in vivo formulation: Take L DMSO master liquid, next addL PEG300, mix and clarify, next addL Tween 80, mix and clarify, next add L saline, mix and clarify

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35 Cutaneous manifestations of mixed cryoglobulinemia are diverse and can include palpable purpura of the lower extremities, Raynauds phenomenon (white coloration and numbness of the fingers upon exposure to cold), secondary acrocyanosis (asymmetric, persistent, blue discoloration of fingers or toes), and livedo reticularis (reticular cyanotic pattern with mottling, typically of the lower extremities) [Figure 14]
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& Zhang, H

J Clin Invest 121 , 12311241, doi: 10.1172/JCI44145 (2011)
