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Compared to healthy individuals, RA patients exhibit lower expression of ACSL4 and increased levels of ferritin heavy chain 1 (FTH1), GPX4, and SLC7A11 in the synovium and FLS

The majority of vertebrates use the oxidation of oxygen molecules to create energy

While bevacizumab - a humanized anti-VEGF monoclonal antibody approved since 2004, its clinical efficacy is limited by compensatory mechanisms and acquired resistance (96)

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