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These reagents support two clinically relevant concepts: (1) Combination sensitization: FSP1 blockade can sensitize tumors to upstream ferroptosis-inducing nodes (for example, GPX4 inhibition or cystine import disruption), consistent with the idea that tumors rely on redundant antioxidant systems

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The TGR dsRNA treatment led to a significant decrease in both TGR mRNA and enzymatic activity, while treatment with irrelevant dsRNA had no effect