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*Correspondence: Changgang Sun, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Cellular Biochemistry, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The metabolic heterogeneity of diverse tumor types, varied clinical stages, distinct cell populations within the TME may be one of the factors contributing to the poor efficacy of metabolic-targeted drugs

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