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Keywords: fatigue, multiple sclerosis, orexin, sleep disturbances, physical activity, amantadine Introduction Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system (CNS), and is the most common cause of chronic neurological disability in young adults

[228] of the eleven carbonic anhydrase enzymes it examined, it found that amphetamine potently activates seven, four of which are highly expressed in the human brain, with low nanomolar through low micromolar activating effects