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Glucose deprivation reduces the PPP-mediated NADPH generation, making it impossible to reduce insoluble cystine imported via xCT to a more soluble cysteine, thereby inducing disulfide stress (i.e., cystine-dependent toxicity) and leading to rapid cell death [48] [Figure 3B]

the subject in need thereof may be a subject identified as being a responder based on: the subjects and control groups may be children

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Mitochondrial dysfunction, identifiable through Krebs cycle intermediates on OAT, has been linked to persistent fatigue and neurocognitive symptoms in a systematic review by Rossignol and Frye (2012)

Editor information Editors and Affiliations Rights and permissions Copyright information 2026 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Sturza, A., Furdui-Lina, A.V., Buriman, D., Ionic, L.N., Lighezan, R., Muntean, D.M