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When at least 10 studies were available for each treatment against placebo, publication bias and small-study effects were examined visually using the comparison adjusted funnel plot under the fixed-effect model.3 When a funnel plot asymmetry was detected, we performed the Copas selection for the treatment comparisons that were informed by at least 10 studies and for which asymmetry was evident in the funnel plot

[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Calder, P

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Disulfiram (#HY-B0240, MCE), Copper (II) chloride dihydrate (#C3279, Sigma-Aldrich), N-acetylcysteine (#HY-B0215, MCE), ISD (#tlrl-isdn, InvivoGen), diABZI (#S8796, Selleck), DMSO (#D8418, Sigma-Aldrich) were purchased from the indicated manufacturers

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Given the cellular heterogeneity of the liver and the complex intercellular crosstalk involved in disease progression (28), we then asked whether GSH depletioninduced suppression of lipogenesis and fibrosis is intrinsic to hepatocytes