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Hexosamine pathway Excess glucose not metabolized via glycolysis can enter the hexosamine pathway, which leads to increased production of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), which is used for O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins

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As such, it regulates critical cellular processes such as metabolism of estrogens, prostaglandins, leukotrienes, and xenobiotic drugs

3-O-Me-N-Me--MeDA HO : Hydroxyl radical 5-HT: 5-Hydroxytryptamine, Serotonin 5-HTT: Serotonin transporter