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The Unfolded Protein Response and Hepatic Lipid Metabolism in Non Alcoholic Fatty Liver Disease

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Neuroprotection and Neurodegenerative Disease The brain is particularly vulnerable to oxidative stress due to its high oxygen consumption rate (20% of total body O 2 ), abundance of peroxidation-susceptible polyunsaturated fatty acids, relatively low antioxidant enzyme expression compared to liver, and high iron content in specific regions (substantia nigra, striatum)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 138.Slika, H