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In those preclinical models it has been reported to promote angiogenesis the growth of new blood vessels through the VEGFR2AkteNOS / nitric-oxide pathway, which may help explain its observed effects on healing [1] [4]

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GH-RH also regulates the insulin-like growth factor-I (IGF-I) by activating the pituitary GH/liver IGF-I axis 58

Moreover, patients with chronic liver disease often exhibit disturbed iron homeostasis, further exacerbating the progression of liver injury [5]

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Takeshima N, Sozu T, Tajika A, Ogawa Y, Hayasaka Y, Furukawa TA