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Discovery and activity of (1R,4S,6R)-N-[(1R)2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]1-piper idinyl]1-[(4-fluorophenyl)methyl]2-oxoethyl]2-methyl-2-azabicyclo[2.2.2]octane 6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist

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