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Finally, we investigated whether the functional mitochondrial defects in ccOzz / and, to a lesser extent, Alix / myotubes were associated with histochemical changes in the muscle tissue, as typically observed in human mitochondrial myopathies 10,12

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Mitochondrial bioenergetic dysfunctions may also have broader impact on immune processes

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Cassina et al., Role of glial cells in metabolism and ALS Although ALS is mainly characterized by the selective loss of motor neurons, neighboring non-neuronal cells such as astrocytes (Clement et al., 2007), microglia (Beers et al., 2008

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