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Data extracted from the studies included the author, date of the study, baseline characteristics of patients (underlying autoimmune disease, age, sex), total number of subjects, study duration, treatment, number of patients in each medication group, duration of treatment, person-years, HZ definition, and incidence of HZ within the different medication groups

Subsequent research revealed multiple mechanisms behind its antinociceptive effect, including activation of nitric oxide (NO)-dependent cGMP pathways [209], CB2 cannabinoid receptor activation [210], and TRPA1 channel desensitization [211]

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It modulates the nitric oxide system, improving blood flow to injured areas

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