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Owing to inherent variations in molecular configurations and constituent elements among different ADCs, these molecules are more likely to be recognized as foreign antigens by the immune system, which may trigger an immune response characterized by the production of anti-drug antibodies (ADAs)

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Another pathway of interest is the mitogen activated protein kinase (MAPK) cascade, which can be activated by H 2 O 2 and subsequently translocated into the nucleus to activate specific transcription factors (Lebrun-Garcia et al

The inflammasome can be activated through various stimuli, including danger-associated molecular patterns and pathogen-associated molecular patterns (66)

Mechanisms and therapeutic targets of ischemic acute kidney injury