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Over 42 days, the ethanol group received 20% ethanol in their drinking water, while losartan was administered intraperitoneally at doses of 1 mg/kg and 3 mg/kg to the treatment groups.The results demonstrated that losartan significantly reduced oxidative stress markers, evidenced by decreased levels of malondialdehyde and increased total thiol levels in renal tissues

Clinical manifestations commonly include abdominal pain, diarrhea (with or without hematochezia), and weight loss

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Cartilage and osteoarthritis models published research has explored AOD-9604 in articular cartilage and chondrocyte models, sometimes in combination with HA or other matrix peptides

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