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Drugs such as the antimicrobial vancomycin (which may cause Red man syndrome) [9], nonsteroidal anti-inflammatory drugs (NSAIDs), neuromuscular blockers for anesthesia, opioid analgesics, such as morphine, radiocontrast media, and a variety of other less often used medications can directly stimulate degranulation of mast cells and release of histamine [10]

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doi: 10.1200/JCO.2008.19.1635

Combination of high-dose parenteral ascorbate (Vitamin C) and alpha-lipoic acid failed to enhance tumor-inhibitory effect but increased toxicity in preclinical cancer models

Further, complicating this scenario is the activation of the HPA axis, which leads to heightened levels of the primary stress hormone, corticosterone (CORT)

This structure makes oxygen especially susceptible to radical formation