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For example, MEK inhibition leads to strong overrepresentation of ERK1/2 motif as expected, GSK3 inhibition down-regulates sites that conform to the known GSK3 motif, and mTOR inhibition down-regulated sites with the known mTOR substrate motif as well as substrate sites of its main downstream kinase p70S6K

Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart

This selective activity has made it a candidate of interest in obesity-related investigations

Among these nine drugs, CP21R7 and BIO, which are GSK3 beta inhibitors, have been reported to have Wnt signal activation effects
Lu H, Clauser KR, Tam WL, et al

Initially, doses are given daily or weekly until levels normalize and maintained monthly afterward
