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Oxidative stress biomarkers were evaluated in blood plasma, liver, kidney and spleen tissues

Recent studies demonstrated that the miRNA-Responsive Autoregulatory Element (miRARE) effectively reduced toxicity in self-complementary AAV9 miniMECP2 gene therapy in mice (119)

Without intervention, immunosenescence significantly contributes to morbidity and mortality among the elderly, intensifying healthcare burdens and diminishing quality of life on both individual and societal levels

As an example, mercury, lead, cadmium and manganese all damage the central nervous system but with consequences of very different nature

Supplementary Material Acknowledgments This work was supported by Key research projects on modernization of traditional Chinese medicine, National Key R&D Program (2018YFC1706900)