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The structural changes in IGF-1 LR3 (the arginine substitution and 13-amino-acid extension) drop binding-protein affinity sharply

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The tumor suppressor p53 activates GLS-2 expression, regulates intracellular ROS levels and reduced/oxidized GSH ratios, and removes intracellular ROS to protect cells from genomic damage and ROS-sensitive apoptosis [18, 19]
