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Similarly, intestine-specific Znt10 KO revealed moderate systemic Mn accumulation, whereas intestine and liver double Znt10 KO resulted in severe Mn overload compared to either KO alone (Mercadante et al., 2019), suggesting that both intestine and liver ZNT10 play an essential role in Mn excretion

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These carriers improve the solubility of poorly water-soluble drugs and accommodate multiple therapeutic agents, making them versatile for oral, transdermal, and topical applications (Mahmoudian et al., 2021)

Injection allows precise dosing with minimal waste