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10.1089/ARS.2009.2466 40 HolmgrenA

The role of aldose reductase in polyol pathway: an emerging pharmacological target in diabetic complications and associated morbidities

As the direct reaction species to react with Si-based agent is hydroxide ions, the higher the pH of the reaction solution, the greater the amount of hydrogen generated from Si-based agent

The aim was to assess whether the C677T polymorphism has an influence on achieving greater weight loss during weight loss therapy in patients and whether the genotype can contribute to maintaining the effects of this therapy over a longer period

Mechanistically, TNF- acts as a central mediator by binding to its receptor tumor necrosis factor receptor 1, subsequently triggering the activation of NF-B, mitogen-activated protein kinases (MAPKs) and c-Jun N-terminal kinase (JNK) pathways (53)

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