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Nrf2 works in combination with small avian musculoaponeurotic fibrosarcoma oncogene homolog (MAF) proteins: together they recognize and bind antioxidant response elements (ARE) in promoters of antioxidant enzyme genes (phase 2 enzymes such as glutathione S-Transferase (GST), UDP-glucorosyl transferase and superoxide dismutase (SOD), GSH peroxidase (GPx) and catalase (CAT), sulfiredoxin 1 and Thioredoxin reductase 1 [16,17,18,19]

Nearly all positive human studies have been small, uncontrolled, and authored by people selling the peptide

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