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The CD36 receptor, which is highly expressed on the surface of CD8+ T cells, promotes lipid droplet formation and increases the content of PUFAs in membrane phospholipids by mediating the uptake of palmitic acid and arachidonic acid, ultimately inducing ferroptosis ( Additionally, under the stimulation of DAMPs, T cell responses exhibit a dual-track regulatory mechanism

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Minerals like magnesium and antioxidants such as glutathione play a key role in this process
