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Glutathione exists in cells in 2 states: reduced Glutathione (GSH) and oxidized Glutathione (GSSG)

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Elimination of NADPH oxidase activity promotes reductive stress and sensitizes the heart to ischemic injury

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Sch A and Sch B can suppress the proliferation of Th1 cells (which promotes inflammation) via the depletion of GSH and a reduction in the release of Th1 cytokines in Con A-activated T lymphocytes

As already described for diabetes, the combination low GSH/low NO leads to a higher calcium influx into the vessel wall and in smooth muscle with vasoconstriction, as demonstrated also in animal models [75]