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Supporting a healthy detoxification process of both endogenous and environmental toxins is another critical function of glutathione in the body

Glutathione depletion up-regulates Bcl-2 in BSO-resistant cells

The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K 3 , sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca 2+ absorption