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Briefly, HMZCO/DS@CM (2 mg/mL) was placed in a dialysis tube (MWCO: 3500 Da) and placed in 10 mL of release medium, including PBS buffer (pH = 5.5 or 7.4), 0.9% NaCl, and DMEM supplemented with 10% FBS, at 37 C under gentle agitation

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It is higher than that of water (around 0.15 17 ), which does not dissolve cisplatin, and similar to that of cisplatin-dissolving DMSO (0.83 18 )

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