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In general, antioxidative proteins were more abundant in healthy compared to tumor tissue (Supp

doi: 10.1016/S0171-2985(96)80017-9

Necroptosis happens when the caspase activity necessary for apoptosis is inhibited in response to TNF, Fas, or TRAIL, as well as certain toll-like receptor (TLR) ligands (104)

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Given the laboratory and clinical findings, the initial differential diagnosis focused on hematologic malignancies, including leukemia, lymphoma, and myelofibrosis

These effects appear to be mediated, in part, by TLR4 expressed on macrophages [136]