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Calves (up to 1 year): 1mL/50 kg Cattle (1-2 years): 1mL/75 kg Cattle (over 2 years): 1mL/100kg Cows: 3 4 weeks before calving, mating and drying off Calves: At day 1 and weaning Heifers: Every 3 months, especially 3 4 weeks before mating Additional: Every 2 months in wet conditions WITHHOLDING PERIODS No withholding period is required when used as directed

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CC 50 values measured for atpenin A5 based on MTT and CTG closely mimic the IC 50 , with 3.6 M (MTT) and 1.0 M (CTG), respectively

In the future, this mechanism might also extend to novel treatments of other neuroinflammatory and neurodegenerative conditions. Additional authors on the study include Deepa Jonnalagadda, Manisha Ray, Clayton Ellington and Richard Rivera, all at Sanford Burnham Prebys, Aran Groves, Sanford Burnham Prebys and UC San Diego