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Recently, the ubiquitination-independent functions of cereblon have been studied, which include its function as a transcription repressor, chaperone protein, and scaffold protein 37

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Furthermore, NRF2 enhances drug resistance by inducing the expression of ATP-binding cassette (ABC) transporters such as ABC sub-family C member 1 (ABCC1) and ABC sub-family G member 2 (ABCG2), which efflux chemotherapeutic agents out of cells
