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The localization of NQO1 in epithelial and endothelial tissues of mice, rats and humans indicates their importance in detoxifying agent, since their location facilitates exposure to compounds entering the body

Another study showed that taking selenium supplements increased glutathione peroxidase levels in patients on hemodialysis

39: e2017036

ALLOIMMUNE (TRANSFUSION) HEMOLYTIC ANEMIA The most severe alloimmune hemolysis is an acute transfusion reaction caused by ABO-incompatible red blood cells

However, when glucose is deficient, the insufficient supply of NADPH leads to the inability to timely maintenance of redox homeostasis, resulting in the abnormal accumulation of disulfides (such as cystine) within cells, which triggers a stress response

It is commonly combined with Chrysanthemum morifolium (to clear heat and suppress the hyperactive liver), Arisaema cum bile (to resolve phlegm and calm endogenous wind), and Paeonia suffruticosa (to cool the blood and disperse stasis) as core couplet medicines (Lu et al., 2021)