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Ca 2+ homeostasis imbalance Upon the release of the excitatory neurotransmitter glutamate from the presynaptic terminal, it initiates the activation of postsynaptic receptors, thereby inducing alterations in the electrical potential across the postsynaptic membrane

Meanwhile, Zn deficiency in Arabidopsis reduced primary root length while increasing the number and length of lateral roots (Jain et al., 2013)

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Given the essential role of astrocytes in clearing and detoxifying many substances and the changes in astrocyte functions that such substances can evoke, it is interesting to consider (and worthy of more extensive investigation) that chronic exposure to trace amounts of such substances might act as risk factors and comorbidities in a variety of CNS neurodegenerative conditions