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In one crystal form, the direct hydrogen-bonding interaction between the hydroxyl group of Tyr7, a residue involved in catalysis, and the thiol group of the substrate, glutathione, is broken and replaced by a water molecule that mediates the interaction

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Cystathionine-beta-synthase: Linking Sulfur Amino Acid Metabolism, Oxidative Defense, and Cell Signaling Table of Contents Cystathionine-beta-synthase, usually called CBS, is one of those enzymes that looks simple at first but quickly becomes important once you start looking at metabolism in detail