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Brito-Zern, P., Retamozo, S

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In cultured lymphoblastoid cell lines, -N-trimethyllysine hydroxylase activity is undetectable or severely reduced in patients with mutations or deletions in the TMLHE gene

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Furthermore, H3K18la transcriptionally activates the expression of heterogeneous nuclear ribonucleoprotein C (HNRNPC), which acts as an m6A reader to stabilize TNF receptor-associated factor 6 (TRAF6) mRNA, ultimately promoting TRAF6-mediated gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC) [81]