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Alpha-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Therefore, to experimentally compare the outcomes of ABHD11 inhibition to glutarate accumulation, we used HeLa cells as a well-studied cancer cell line, alongside primary human CD8 + T lymphocytes, where the effects of DEG have been well characterized 9

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The mutagenicity of LSO-NE was evaluated using an in vitro Ames/Salmonella assay, which indicated no mutagenic effects on Salmonella typhimurium strains TA98 and TA100

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