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Although, zopolrestat and tolrestat were discontinued due to severe hepatotoxicity and an unfavorable risk-benefit profile observed in phase 2 and phase 3 clinical trials, respectively [150,151,152], and ranirestat, which also progressed through phase 3 trial, focused primarily on diabetic polyneuropathy rather than cardiovascular outcomes [153]

Such disruptions contribute to imbalances in redox conditions and increased reactivity within the system environment

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Yan, J., Kuzhiumparambil, U., Bandodkar, S., Dale, R

Therapeutic antibodies and fusion inhibitors targeting the spike protein of SARS-CoV-2