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For example, sphingosine-1 phosphate inhibits apoptosis induced by ceramide, a well-established inducer for both apoptosis and autophagy, but induces autophagy 46

Severe B6 deficiency is known to cause seizures in infants because GABA production drops without enough P5P

213 The key molecular mechanism is the suppression of NF-B pathway activated by cytokines such as TNF- and IL-1

Lpez-CarrilloLLpez-CervantesMRobles-DazGRamrez-EspitiaAMohar-BetancourtAMeneses-GarcaAet al

doi:10.1016/j.cyto.2020.155239 16 (2021) N-acetyl cysteine

GLS1 interacts with Kelch-like ECH-associated protein 1 (KEAP1) to release nuclear factor erythroid 2-related factor 2 (NRF2), enhancing antioxidant defenses and promoting chemotherapy resistance, while glutamine-derived glutamate activates mTORC1 via Rag GTPases [62,94]