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In neurons, glutamate is then packaged into synaptic vesicles by vesicular glutamate transporters (VGLUTs) and stored in the presynaptic terminal before release

Another multitarget MOR-DOR agonist, SRI-22141, was tested in the clinically relevant models of HIV neuropathy and chemotherapy-induced peripheral neuropathy, in which it was found that while providing equal or enhanced efficacy versus morphine, the tolerance was significantly reduced, with almost non-dependence during the course of repeated administration [59]

Donnelly MJ, Corbel V, Weetman D, Wilding CS, Williamson MS, Black WCt: Doeskdrgenotype predict insecticide-resistance phenotype in mosquitoes?Trends Parasitol2009, 25(5):213-219

Biomarker of abnormal energy metabolism in children with autism spectrum disorder