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Summary MCAS is a heterogeneous disorder demanding a personalized therapeutic approach and, especially when presenting as anaphylaxis, has not been formally captured as outcome in prospective clinical trials with TKI
Determination of single-strand DNA (ssDNA) breaks, mitochondrial membrane depolarization, caspase cleavage and DNA fragmentation Cells were seeded, pretreated with BSO (400 M) for 24 h followed by treatment with L-PAM (30 M)
Perioperative elevations in C4, IL-6, and IL-10 ( Supplementary Table 2 ) mirror the acute pro-inflammatory/compensatory pattern and complement involvement described in SJS/TEN, providing supportive but non-specific evidence for this threshold-lowering hypothesis
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These disruptions also cause significant changes in the expression of numerous proteins and enzymes involved in energy metabolism
Campos L, Galvao VR, Kalil J, Castells M, Giavina-Bianchi P (2019) BAT in the diagnosis of drug allergy: a novel tool in clinical daily practice
