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showed that pretreatment of cetuximab-resistant KRAS mutant CRC cell lines with crizotinib blocked radiation-induced c-MET phosphorylation, attenuated radiation-induced Akt activation, increased radiation-induced DNA damage, and prolonged DNA double-strand break repair (Cuneo et al., 2019)

Many chemotherapeutic drugs can induce autophagy, which is one of the important factors for tumor cells to develop drug resistance

Science 326(5960):16941697

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Oncotarget 7, 2949229506