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A new covalent GPX4 inhibitor, C18, shown strong inhibitory efficacy against TNBC cells and substantial tumour growth suppression in a xenograft model, with no apparent toxicity [268]

In this work, curcumin improved male reproductive health and histopathological changes

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Animal studies have shown that 95% hyperoxia substantially enhanced cellular ROS generation, increased apoptosis, induced TRX-1 and TRXR-1 expression while the TRXR-1 activity was reduced