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Numerous studies have reported that NNMT has an inhibitory effect on the aerobic metabolism of sugars and fats, and NNMT Knockdown can increase oxygen consumption, promote sugar consumption and reduce fat synthesis, but the effects of NNMT on anaerobic energy metabolism have not been reported

Delplanque J, De Loof E, Janssens C, Verguts T (2019) The sound of beauty: how complexity determines aesthetic preference

Selected Preclinical Data Study 1: Genetic Proof-of-Concept A seminal investigation reported elevated NNMT expression in white adipose tissue (WAT) and liver of obese/diabetic mice

It does not activate the hGH receptor or raise IGF1 levels, and it has no meaningful effect on blood glucose or insulin sensitivity

Combining an NNMT inhibitor and bevacizumab contributes to improving survival (63)

Several RNAi drugs, including aptamers like pegaptanib targeting protein targets, and micro interfering RNAs like givosiran and patisiran, as well as antisense oligonucleotides like golodirsen and inotersen that interfere directly with RNA targets, have received FDA approval for medical use (Yu et al., 2020)