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Most published data comes from animal and laboratory studies, and human clinical trials are lacking, so human efficacy is not established [1]

Through animal experiments that extracellular vesicle miR-22-5p_R-1 inhibits the metabolic shift from mitochondrial respiration to glycolysis (MGS) in the trophoblast and suppresses trophoblastic EMT, increasing the likelihood of RM (Xiong et al., 2024)

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To further confirm Nrf2s involvement in the ER calcium regulation process via GPX8, in the same study, after silencing Nrf2 in HeLa cells, GPX8 mRNA and protein levels also decreased, resulting in elevated ER and cytosolic calcium levels at rest and increased histamine-induced ER calcium release (Granatiero et al., 2019)