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Genital lesions, especially those occurring in the vulva, often show more prominent atypical features, such as moderate to severe cytologic atypia (epithelioid cells with prominent nucleoli) and occasional pagetoid spread

Malignant peripheral nerve sheath tumor of non-neurofibromatosis type I metastasized to the cerebrospinal axis

16 The Fontana-Masson stain, which identifies melanin, may be helpful in the diagnosis of subungual melanoma, with an increased number of pleomorphic melanocytes, florid pagetoid cells, atypia and multinucleation observed in the basal layer of the specimen

These mutants were biochemically analyzed, revealing an altered topology of the Ca 2+ -binding site, thus proposing the role of this region of CRP in its binding to A, with the authors ultimately concluding that CRP is a dual pattern recognition molecule and an antiamyloidogenic protein as well [126]