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Generally, tonic firing of DA neurons (18 Hz) sets the background dopaminergic tone, which is sufficient to stimulate the high-affinity DA D2 receptors (D2R), whereas phasic firing ( 15 Hz) encodes responses to salient stimuli (rewarding, unexpected, novel, aversive) and results in higher DA levels (120) that are able to stimulate the low-affinity DA D1 receptors (D1R)

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Blood 104:565a, 2004

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One percent of people over the age of sixty have PD

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