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Nicotinamide also upregulates NAD+ metabolism, supporting mitochondrial health in regulatory T cells and enhancing their immunosuppressive capacity (125)
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KQD conceived and directed the whole study, and contributed to the writing
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Trends Cancer 2 , 241251 (2016)
Interestingly, astrocytes often do not transition into this more damaging/senescent-like state unless microglia induce the switch through the release of cytokines like IL-1 and TNF (Herx et al., 2000
