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Bacterial labyrinthitis, especially when caused by invasive organisms such as Streptococcus pneumoniae or Haemophilus influenzae type B (Dodge et al., 1986) is devastating to the delicate tissue of the inner ear, and immunization against these pathogens provides significant protection (Schuchat et al., 1997)
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2001;90((Suppl
(2020) 10:e12027
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The two methyl groups at the 3- and 5-positions fill a hydrophobic cleft that collapses in the absence of ligand, stabilizing the TM1-TM7 interface in the active conformation
