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DSIP is supplied as a lyophilised powder and is reconstituted prior to use with sterile bacteriostatic water

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In most cases, drug-induced hair graying is reversible by reducing the dose or discontinuing the offending medication

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Interestingly, ()-epigallocatechin-3-gallate (EGCG), the major constituent of green tea that has potent antioxidant action, was shown to block the inhibitory effect of TGF-1 on GCLC expression and GSH levels in HSCs and TGF-1-induced HSC activation (Fu et al., 2008)

There are also reports that rupture of the respiratory or intestinal epithelial barrier and weakening of other barriers, for example, the bloodbrain barrier or the vascular endothelial barrier, may facilitate the development of metabolic and autoimmune diseases [55, 81,82,83,84]